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Throughout the animal kingdom, several species have the ability to regenerate body parts after cuts or damage.A new study examines the genomes of five different animal species—axolotl, zebrafish, sea anemones, sea sponges, and sea cucumbers—that all have the ability to regenerate, but are evolutionarily distinct (counterintuitively, the sea creatures are not very closely related).
“We’re arguing that RNA-seq is not good enough on its own to identify conserved processes across distantly related things,” says senior author David Gold, a former Caltech postdoctoral scholar and now associate professor at UC Davis. “Regeneration could be a conserved process at other levels, like the cellular level rather than the genetic. To really resolve whether there is anything ancient and conserved in these organisms is going to require careful developmental biology studies of figuring out what precise role each gene plays in regeneration.”
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